- Deal value of US$ 1 billion with US$ 130 million upfront, - Novo Holdings co-created Syndesi Therapeutics in partnership with UCB Pharma and co-led the Series A financing, - Syndesi's lead program SDI-118 to be accelerated by AbbVie to the benefit of patients suffering from cognitive impairment associated with a range of neurodegenerative and neuropsychiatric diseases. The mechanism is currently being evaluated . profile. Phone Number +32 10 280 238. To get there, he's had to face down many challenges, including a fashion industry that's often held back Black designers. Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). from 8 AM - 9 PM ET. It has been a pleasure to partner with Novo Seeds, UCB and our other investors to investigate the potential of SDI-118 in early clinical studies. Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). UCB identified novel modulators of SV2A that show pro-cognitive properties in preclinical models. Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic . As a life science investor, Novo Holdings provides seed and venture capital to development-stage companies and takes significant ownership positions in growth and well-established companies. The UK Life Sciences team advised Syndesi Therapeutics and its shareholders on Syndesi's acquisition by AbbVie (NYSE: ABBV). Medical. Novo Holdings A/S is a private limited liability company wholly owned by the Novo Nordisk Foundation. AbbVie announced it has completed the acquisition of Syndesi Therapeutics SA, which will help to expand AbbVie's neuroscience portfolio. Syndesi Therapeutics is developing molecules that modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). Cambridge, Massachusetts, United States 62 Contacts11-50 employees. Macrophage Therapeutics has developed a proprietary targeted steroid (MT-2000 class) designed to specifically treat the disease-causing cells quarterbacking the body's inflammatory response (Macrophages). Company Presentation . The investment in Syndesi is an integral part of Novo Seeds' approach to new venture formation by co-leading spinouts from pharmaceutical companies based on assets that are no longer in-line with the corporation's overall strategy. Dyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases. Jonathan Savidge, Chief Executive Officer, Syndesi Therapeutics, said: We have been impressed with the vision of AbbVies neuroscience R&D team, who share our view on the therapeutic potential of SDI-118 in a range of neurologic diseases. Jonathan Savidge, Chief Executive Officer, Syndesi Therapeutics, said: "We have been impressed with the vision of AbbVie's neuroscience R&D team, who share our view on the therapeutic potential of SDI-118 in a range of neurologic diseases. The Company's approach is aimed at treating Alzheimer's Disease and other disorders with cognitive impairment. Syndesi Therapeutics. Confo has attracted an international team of accomplished scientists and business professionals to deploy its innovative . According to the deal, shareholders of Syndesi will receive an upfront payment of $130m from AbbVie. Syndesi Therapeutics General Information. AbbVie will pay Syndesi shareholders an upfront payment of $130m as part of the deal, but could make additional payments of up to $870m if certain predetermined milestones are hit. 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I am delighted with the announcement of this deal. Syndesi Therapeutics is one of several Novo Seeds portfolio companies focused on developing better treatments for CNS disorders, an area of significant unmet medical need. About Syndesi Therapeutics. March 01, 2022. Regulating synaptic transmission represents a promising approach to treating Alzheimers Disease and other disorders with cognitive impairment. Syndesi Therapeutics SA operates as a biotechnology company. Jonathan Savidge and the Syndesi team have developed a portfolio of novel SV2A modulators to treat synaptic transmission deficits associated with cognitive dysfunction across a range of neuropsychiatric and neurodegenerative disorders such as Alzheimer's Disease, Parkinson's Disease, schizophrenia, and depression. AbbVie has acquired Belgium-based company Syndesi Therapeutics in a deal worth up to $1bn, expanding its neuroscience portfolio.. Find out more about how we use your information in our privacy policy and cookie policy. MT-2000 is a class of agents that are designed to precisely convert pro-inflammatory M1 Macrophages to anti-inflammatory M2 macrophages. Regulating synaptic transmission represents . Syndesi Therapeutics is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment seen in multiple CNS disorders, including Alzheimers Disease, schizophrenia and depresson. Syndesi Therapeutics is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. Syndesi was created in 2018 as the result of a close collaboration between Novo Seeds, the company creation arm of Novo Holdings, and UCB Pharma, the Belgium-based global pharmaceutical company. Syndesi's unique molecules act pre-synaptically to enhance synaptic efficiency by . Provides strong support for the initiation of further clinical trials in cognitive impairment. Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. You can change your choices at any time by visiting your privacy controls. The Company specializes in neurology drug discovery to develop potential therapeutics in cognitive disorders. Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American. This acquisition gives AbbVie access to Syndesi's portfolio of novel modulators of the synaptic vesicle protein 2A (SV2A), including its lead molecule SDI-118. Developing novel SV2A modulators as potential treatments for cognitive impairment | Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). Cision Distribution 888-776-0942 In this process the team has added significant insights into the biology of SV2A and the mechanism of action of the Companys lead program SDI-118. Syndesi Therapeutics raised $21254941 on 2018-02-15 in Series A. Novo Seeds Novo Seeds identifying, building and investing in exceptional startups. Information about your device and internet connection, like your IP address, Browsing and search activity while using Yahoo websites and apps. They are also entitled to get further contingent payments of up to $870m on meeting specific pre-set milestones. Syndesi Therapeutics was established to develop a series of novel, pro-cognitive small molecule SV2A modulators licensed from UCB. The investment in Syndesi is an integral part of Novo Seeds approach to new venture formation by co-leading spinouts from pharmaceutical companies based on assets that are no longer in-line with the corporations overall strategy. Celebrity tailor and designer Rich Fresh has made a name for himself in Los Angeles as a luxury athleisure designer. Novo Holdings also manages a broad portfolio of diversified financial assets. For further information Dyne Therapeutics. With the support of our investors and other stakeholders, Syndesi's goal is to demonstrate the potential of these molecules to reduce the symptoms of . Company profile page for Syndesi Therapeutics SA including stock price, company news, press releases, executives, board members, and contact information Syndesi Therapeutics serves customers worldwide. 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